Acute Kidney Injury and Hepatic Dysfunction

Paneth cell-mediated multiorgan dysfunction after acute kidney injury.

Acute kidney injury (AKI) is frequently complicated by extrarenal multiorgan injury, including intestinal and hepatic dysfunction. In this study, we hypothesized that a discrete intestinal source of proinflammatory mediators drives multiorgan injury in response to AKI. After induction of AKI in mice by renal ischemia-reperfusion or bilateral nephrectomy, small intestinal Paneth cells increased ...

Renal endothelial dysfunction in acute kidney ischemia reperfusion injury.

Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. Putative mediators of vasoconstriction that may contribute to the initial loss of renal blood flow and ...

0889. Mitochondrial dysfunction contributes to sepsis-induces acute kidney injury

Methods Multiphoton confocal microscopy images were recorded over 45 minutes in intact renal sections (taken from healthy rats) incubated in either physiologic saline solution (PSS) (n = 6), sham serum (n = 3), septic serum (n = 3), and septic serum co-incubated with 10nM of the anti-oxidant 4-OH-Tempo (n = 4). Pooled septic serum was obtained from (n = 5) rats 24 hrs after induction of faecal ...

Different Biomarkers of Acute kidney Injury in Cancer Patients

Acute Kidney Injury (AKI) occurs if the kidneys suddenly lose their ability to remove waste products. When the kidneys lose their ability to filter, dangerous levels of waste products can accumulate, which can upset the chemical composition of the blood and urine. Chemotherapy is one of the methods used to treat or temporarily reduce cancer by using certain medications. The main task of this tr...

NGAL, the New Marker for Acute Kidney Injury